2024

An optimized Langendorff-free method for isolation and characterization of primary adult cardiomyocytes (2024). Nikouee A, Yap JQ, Rademacher DJ, Kim M, Zang QS. BMC Cardiovascular Disorders; 24(1): 256. doi.org/10.1186/s12872-024-04256-5

Macrolide Resistance in the Aerococcus urinae Complex: Implications for Integrative and Conjugative Elements (2024). Lamichhane J, Choi BI, Stegman N, Fontes Noronha M, Wolfe AJ. Antibiotics; 13 (5): 433 doi.org/10.3390/antibiotics13050433

Microbroth dilution method for antibiotic susceptibility testing of fastidious and anaerobic bacteria of the urinary microbiome (2024). Geaman W, Choi BI, Kaindl J, Gonzalez C, Wolfe AJ. Microbiol Spectr; 12 (6): e0031424 doi: 10.1128/spectrum.00314-24

Complete genome sequences of Aerococcus loyolae ATCC TSD-300(T), Aerococcus mictus ATCC TSD-301(T), and Aerococcus tenax ATCC TSD-302(T) (2024). Choi BI, Fontes Noronha M, Kaindl J, Wolfe AJ. Microbiol Resour Announc; 13 (6): e0015624 doi: 10.1128/mra.00156-24 DOI: 10.1128/spectrum.00314-24

Reducing the Environmental Impact of Health Care Conferences: A Study of Emissions and Practical Solutions (2024). Lichter KE, Sabbagh A, Demeulenaere S, et al. JCO Global Oncology; (10): e2300209 doi: 10.1200/go.23.00209

High-fat diet-induced AKT-palmitoylation in hepatocellular carcinoma: a breakthrough mechanistic investigation (2024). Keating CR, Calvisi DF, Qiu W. Gut; 73 (7): 1046 doi: 10.1136/gutjnl-2023-331857

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses (2024). Talley S, Nguyen T, Van Ye L, Valiauga R, et al. Immunity & Ageing; 21 (1): 60 doi: 10.1186/s12979-024-00462-z

Sex-dependent effects of carbohydrate source and quantity on caspase-1 activity in the mouse central nervous system (2024). Valiauga R, Talley S, Khemmani M, et al. Journal of Neuroinflammation; 21 (1): 151 doi: 10.1186/s12974-024-03140-5

2023

Polyamine catabolism is concentrated in tumor-associated histiocytes in diffuse large B-cell lymphoma and classic Hodgkin lymphoma (2023). Bronson AS, Lilley CM, Zleczewski M, Mirza KM. Pathol Res Pract; 248: 154627 doi: 10.1016/j.prp.2023.154627

Taxonomic considerations on Aerococcus urinae with proposal of subdivision into Aerococcus urinae, Aerococcus tenax sp. nov., Aerococcus mictus sp. nov., and Aerococcus loyolae sp. nov (2023). Choi BI, Ene A, Du J, et al. International Journal of Systematic and Evolutionary Microbiology; 73 (9): doi: https://doi.org/10.1099/ijsem.0.006066

Beyond the usual suspects: emerging uropathogens in the microbiome age (2023). Moreland RB, Choi BI, Geaman W, et al. Frontiers in Urology; 3: doi: 10.3389/fruro.2023.1212590

Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression (2023). Malnassy G, Keating CR, Gad S, et al. Cell Mol Gastroenterol Hepatol; 16 (5): 685-709 doi: 10.1016/j.jcmgh.2023.07.006

Progressive Skull Osteolysis in the Setting of Endotine Implantation: A Case Report (2023). Ma E, Smith S, Simon J, Prabhu V, Pittman A. Ann Otol Rhinol Laryngol: 34894231190969 doi: 10.1177/00034894231190969

Urinary Plasmids Reduce Permissivity to Coliphage Infection (2023). Hernandez CM, Putonti C, Wolfe AJ. Microbiology Spectrum; 11 (4): e01309-23 doi: doi:10.1128/spectrum.01309-23

Report Card Time: How Has the Biden Administration Addressed the U.S. Hispanic Community’s Social Determinants of Health? (2023). Montelongo Hernandez C, Ramirez Alvarado S, Suarez J, Kuczewski M. The American Journal of Bioethics; 23 (1): 7-11 doi: 10.1080/15265161.2022.2135880

Traumatic Brain Injury Induced Inflammation and GI Motility Dysfunction (2023). Cannon AR, Anderson LJ, Galicia K, Murray, M.G. et al. Shock: 10.1097/SHK.0000000000002082 doi: 10.1097/shk.0000000000002082

2022

Sequencing during Times of Change: Evaluating SARS-CoV-2 Clinical Samples during the Transition from the Delta to Omicron Wave (2022). Feng S, Ali MS, Evdokimova M, et al. Viruses; 14 (7): 1408

Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility (2022). Bennett MA, Demeulenaere SG, Wu H, et al. Journal; (Issue): doi: 10.1101/2022.10.10.511341

Environmental Outcomes Associated With Transition From In-Person to a Virtual Oncology Conference During the COVID-19 Pandemic (2022). Lichter KE, Drew T, Demeulenaere S, et al. JAMA Oncol; 8 (9): 1351-1352 doi: 10.1001/jamaoncol.2022.1925

IL-23 Promotes Neutrophil Extracellular Trap Formation and Bacterial Clearance in a Mouse Model of Alcohol and Burn Injury (2022). Li X, Luck ME, Herrnreiter CJ, Cannon AR, Choudhry MA. ImmunoHorizons; 6 (1): 64-75 doi: 10.4049/immunohorizons.2100109

IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury (2022). Luck ME, Li X, Herrnreiter CJ, Cannon AR, Choudhry MA. ImmunoHorizons; 6 (8): 600-613 doi: 10.4049/immunohorizons.2200032

Ethanol Intoxication and Burn Injury Increases Intestinal Regulatory T Cell Population and Regulatory T Cell Suppressive Capability (2022). Luck ME, Li X, Herrnreiter CJ, Choudhry MA. Shock; 57 (2):

The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment (2022). Luck ME, Tao J, Lake EP. American Journal of Clinical Dermatology; 23 (6): 841-852 doi: 10.1007/s40257-022-00724-w

Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression (2022). Sellin M, Mack R, Rhodes MC, et al. Br J Cancer; 127 (2): 223-236 doi: 10.1038/s41416-022-01796-5

SIRT2 regulates proliferation and chemotherapy response of MLL-ENL-driven acute myeloid leukemia (2022). Hao C, Shao X, Song J, Peng M, Lao Y; Mack R et al. Biochem Biophys Res Commun; 596: 36-42 doi: 10.1016/j.bbrc.2022.01.081

The role of TBK1 in cancer pathogenesis and anticancer immunity (2022). Runde AP, Mack R, S JP, Zhang J. J Exp Clin Cancer Res; 41 (1): 135 doi: 10.1186/s13046-022-02352-y

Whole-Genome Sequencing of Staphylococcus aureus and Staphylococcus haemolyticus Clinical Isolates from Egypt (2022). Montelongo C, Mores Carine R, Putonti C, Wolfe Alan J, Abouelfetouh A. Microbiology Spectrum; 10 (4): e02413-21 doi: 10.1128/spectrum.02413-21

Profiling the plasmid conjugation potential of urinary Escherichia coli (2022). Montelongo Hernandez C, Putonti C, Wolfe AJ. Microbial Genomics; 8 (5): doi:10.1099/mgen.0.000814

Roles for GADD45 in Development and Cancer. Patel K, Murray MG, Whelan KA In: Zaidi MR, Liebermann DA, eds. Gadd45 Stress Sensor Genes. Springer International Publishing; 2022:23-39.

Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens (2022). Nguyen M, Osipo C. Int J Mol Sci; 23 (12): doi: 10.3390/ijms23126813

Fluorescence lifetime imaging microscopy reveals sodium pump dimers in live cells 2022). Seflova J, Habibi NR, Yap JQ, et al. J Biol Chem; 298 (5): 101865 doi: 10.1016/j.jbc.2022.101865

Probiotic Molecules That Inhibit Inflammatory Diseases (2022). Zamora-Pineda J, Kalinina O, Osborne BA, Knight KL. Applied Sciences; 12 (3): 1147

2021 

A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection (2021). Gilbert NM, Choi B, Du J, et al. Biology Open; 10 (8): bio058931 doi: 10.1242/bio.058931

Cell surface GRP78 and Dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling (2021). Lager TW, Conner C, Keating CR, Warshaw JN, Panopoulos AD. Oncogene; 40 (23): 4050-4059 doi: 10.1038/s41388-021-01821-6

Integrated analysis of dysregulated microRNA and mRNA expression in intestinal epithelial cells following ethanol intoxication and burn injury (2021). Herrnreiter CJ, Li X, Luck ME, Zilliox MJ, Choudhry MA. Scientific Reports; 11 (1): 20213 doi: 10.1038/s41598-021-99281-1

Gut Microbial Changes and their Contribution to Post-Burn Pathology (2021). Luck ME, Herrnreiter CJ, Choudhry MA. Shock; 56 (3): doi: 10.1097/SHK.0000000000001736

The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies (2021). Mack R, Zhang L, Breslin Sj P, Zhang J. Stem Cell Rev Rep; 17 (6): 2059-2080 doi: 10.1007/s12015-021-10230-x

Characterizing Plasmids in Bacteria Species Relevant to Urinary Health (2021). Montelongo Hernandez C, Putonti C, Wolfe Alan J. Microbiology Spectrum; 9 (3): e00942-21 doi: 10.1128/spectrum.00942-21

Investigation of Plasmids Among Clinical Staphylococcus aureus and Staphylococcus haemolyticus Isolates From Egypt (2021). Mores CR, Montelongo C, Putonti C, Wolfe AJ, Abouelfetouh A. Frontiers in Microbiology; 12: doi: 10.3389/fmicb.2021.659116

DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod (2021). Talley S, Valiauga R, Anderson L, Cannon AR, Choudhry MA, Campbell EM. Journal of Neuroinflammation; 18 (1): 263 doi: 10.1186/s12974-021-02317-6

FXYD proteins and sodium pump regulatory mechanisms (2021). Yap JQ, Seflova J, Sweazey R, Artigas P, Robia SL. Journal of General Physiology; 153 (4): e202012633 doi: 10.1085/jgp.202012633

Amelioration of Graft-versus-Host Disease by Exopolysaccharide from a Commensal Bacterium (2021). Kalinina O, Talley S, Zamora-Pineda J, Paik W, Campbell EM, Knight KL. The Journal of Immunology; 206 (9): 2101-2108 doi: 10.4049/jimmunol.2000780

Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice (2021). Thomas A, Sumughan S, Dellacecca ER, …Zamora-Pineda J, et al. JCI Insight; 6 (22): doi: 10.1172/jci.insight.152014

6-Formylindolo (3, 2-b) Carbazole (FICZ)–mediated protection of gut barrier is dependent on T cells in a mouse model of alcohol combined with burn injury (2020). Li X, Luck ME, Hammer AM, Cannon AR, Choudhry MA. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease; 1866 (11): 165901 doi: https://doi.org/10.1016/j.bbadis.2020.165901

DAXX-inducing phytoestrogens inhibit ER+ tumor initiating cells and delay tumor development (2020). Peiffer DS, Ma E, Wyatt D, Albain KS, Osipo C. NPJ Breast Cancer; 6: 37 doi: 10.1038/s41523-020-00178-5

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches (2020). Zhang L, Mack R, Breslin P, Zhang J. Journal of Hematology & Oncology; 13 (1): 157 doi: 10.1186/s13045-020-00994-z

Biomphalaria glabrata immunity: Post-genome advances (2020). Castillo MG, Humphries JE, Mourão MM, Marquez J, Gonzalez A, Montelongo CE. Developmental & Comparative Immunology; 104: 103557 doi: https://doi.org/10.1016/j.dci.2019.103557

Genomic Survey of E. coli From the Bladders of Women With and Without Lower Urinary Tract Symptoms (2020). Garretto A, Miller-Ensminger T, Ene A, …Montelongo Hernandez C et al. Frontiers in Microbiology; 11: doi: 10.3389/fmicb.2020.02094

Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy (2020). Sinha D, Steyer B, Shahi PK, Mueller KP, Valiauga R, et al. The American Journal of Human Genetics; 107 (2): 278-292 doi: 10.1016/j.ajhg.2020.06.011

2019

Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α. (2019) Kömürlü S, Bradley M, Smolin N, Imam S, et al. PLoS One; 14 (3): e0212888 doi: 10.1371/journal.pone.0212888

K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α (2019). Imam S, Kömürlü S, Mattick J, et al. J Virol; 93 (14): doi: 10.1128/jvi.00558-19

p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts (2019). Mills KA, Quinn JM, Roach ST, Palisoul M, Nguyen M, et al. Scientific Reports; 9 (1): 4762 doi: 10.1038/s41598-019-41122-3

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines (2019). Capowski EE, Samimi K, Mayerl SJ, …Valiauga R, et al. Development; 146 (1): dev171686 doi: 10.1242/dev.171686

Endothelial Dysfunction Is Associated with Mortality and Severity of Coagulopathy in Patients with Sepsis and Disseminated Intravascular Coagulation. (2019) Walborn A, Rondina M, Mosier M, Fareed J, Hoppensteadt D. Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619852163. doi: 10.1177/1076029619852163. PMID:   31140293

Markers of Inflammation and Infection in Sepsis and Disseminated Intravascular Coagulation. (2019) Patel P, Walborn A, Rondina M, Fareed J, Hoppensteadt D. Clin Appl Thromb Hemost. Jan-Dec;25:1076029619843338. doi: 10.1177/1076029619843338. PMID: 30991817

2018

Fork pausing allows centromere DNA loop formation and kinetochore assembly (2018). Cook DM, Bennett M, Friedman B, Lawrimore J, Yeh E, Bloom K. Proceedings of the National Academy of Sciences; 115 (46): 11784-11789 doi: doi:10.1073/pnas.1806791115

Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes (2018). Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Experimental Gerontology; 105: 78-86 doi: 10.1016/j.exger.2017.10.022

Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis (2018). Cannon AR, Kuprys PV, Cobb AN, et al. Journal of Leukocyte Biology; 104 (3): 543-555 doi: 10.1002/JLB.4MA1217-506R

Characterization of regulatory T cells after alcohol intoxication combined with burn injury (2018). Luck ME, Li X, Choudhry MA. Alcohol; 66: 90-91 doi: doi: 10.1016/j.alcohol.2017.11.015

Improved functional outcome after chronic stroke with delayed anti-Nogo-A therapy: A clinically relevant intention-to-treat analysis (2018). Podraza KM, Mehta Y, Husak VA, et al. J Cereb Blood Flow Metab; 38 (8): 1327-1338 doi: 10.1177/0271678x17730994

TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependence (2018). Spear TT, Foley KC, Garrett-Mayer E, Nishimura MI. Journal of Leukocyte Biology; 103 (5): 973-983 doi: 10.1002/JLB.5A0817-314R

Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells (2018). Spear TT, Wang Y, Smith TW, Jr., et al. Mol Ther; 26 (4): 996-1007 doi: 10.1016/j.ymthe.2018.01.015

The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus (2018). Derkac I, Januleviciene I, Sepetiene R, Valiauga R, Velickiene D. Med Sci Monit; 24: 8891-8898 doi: 10.12659/msm.909803

Elevated extracellular nucleosomes and their relevance to inflammation in stage 5 chronic kidney disease (2018). Phan T, McMillan R, Skiadopoulos L, Walborn A, et al. Int Angiol; 37 (5): 419-426 doi: 10.23736/s0392-9590.18.03987-1

Fibrinolytic Deficit and Platelet Activation in Atrial Fibrillation and Their Postablation Modulation (2018). Otto A, Fareed J, Liles J, J, Statz S, Walborn A, et al. Clinical and Applied Thrombosis/Hemostasis; 24 (5): 803-807 doi: 10.1177/1076029617750270

Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation (2018). Jabati S, Fareed J, Liles J, Otto A, Hoppensteadt D, Bontekoe J, Phan T, Walborn A, Syed M. Clin Appl Thromb Hemost. . Clinical and Applied Thrombosis/Hemostasis; 24 (5): 718-723 doi: 10.1177/1076029618761006

Biomarker Profiling in Stage 5 Chronic Kidney Disease Identifies the Relationship between Angiopoietin-2 and Atrial Fibrillation (2018). Bontekoe J, Lee J, Bansal V, Syed M, Hoppensteadt D, Maia P, Walborn A,  et al. Clin Appl Thromb Hemost; 24 (9_suppl): 269s-276s doi: 10.1177/1076029618808909

Plasma C-reactive protein levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment (2018). Edberg D, Hoppensteadt D, Walborn A, Fareed J, Sinacore J, Halaris A. Journal of Psychiatric Research; 102: 1-7 doi: 10.1016/j.jpsychires.2018.02.004

Postoperative Changes in the Systemic Inflammatory Milieu in Older Surgical Patients (2018). Shih L, Guler N, Syed D, Hopkinson W, McComas K, Walborn A, et al. Clin Appl Thromb Hemost; 24 (4): 583-588 doi: 10.1177/1076029617747412

2017

Labeling membrane domains in dividing echinoderm eggs (2017). Bennett M, Meaders J, Ruvolo S, Burgess D. Methods Cell Biol; 137: 1-13 doi: 10.1016/bs.mcb.2016.04.004

Enrichment of dynamic chromosomal crosslinks drive phase separation of the nucleolus (2017). Hult C, Adalsteinsson D, Vasquez PA, J. Lawrimore, M. Bennett, et al. Nucleic Acids Research; 45 (19): 11159-11173 doi: 10.1093/nar/gkx741

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia (2017). Liang K, Volk AG, Haug JS, … Cannova J, et al. Cell; 168 (1-2): 59-72.e13 doi: 10.1016/j.cell.2016.12.011

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling (2017). Li J, Volk A, Zhang J, Cannova J,  et al. Oncotarget; 8 (5): 8420-8435 doi: 10.18632/oncotarget.14220

Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway (2017). Xin J, You D, Breslin P, Li J, Zhang J, Wei W, Cannova J, et al. Leukemia; 31 (5): 1154-1165 doi: 10.1038/leu.2016.287

Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice (2017). Xin J, Breslin P, Wei W, Li J, Gutierrez R, Cannova J, et al. Haematologica; 102 (2): 295-307 doi: 10.3324/haematol.2016.151514

Alcohol Modulation of the Postburn Hepatic Response (2017). Chen MM, Carter SR, Curtis BJ, O'Halloran EB, Gamelli RL, Kovacs EJ. J Burn Care Res; 38 (1): e144-e157 doi: 10.1097/bcr.0000000000000279

Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins (2017). Flavin WP, Bousset L, Green ZC, et al. Acta Neuropathol; 134 (4): 629-653 doi: 10.1007/s00401-017-1722-x

Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection (2017). Dharan A, Opp S, Abdel-Rahim O, Keceli SK, Imam S et al. Proc Natl Acad Sci U S A; 114 (50): E10707-e10716 doi: 10.1073/pnas.1712033114

The Subventricular Zone Response to Stroke Is Not a Therapeutic Target of Anti-Nogo-A Immunotherapy (2017). Shepherd DJ, Tsai SY, Cappucci SP, Wu JY, Farrer RG, Kartje GL. J Neuropathol Exp Neurol; 76 (8): 683-696 doi: 10.1093/jnen/nlx050

FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice (2017). Thompson MG, Peiffer DS, Larson M, Navarro F, Watkins SK. Cancer Immunol Immunother; 66 (5): 615-625 doi: 10.1007/s00262-017-1972-4

Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells (2017). Spear TT, Wang Y, Foley KC, et al. Cancer Immunol Immunother; 66 (11): 1411-1424 doi: 10.1007/s00262-017-2032-9

HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer (2017). Foley KC, Spear TT, Murray DC, Nagato K, Garrett-Mayer E, Nishimura MI. Mol Ther Oncolytics; 5: 105-115 doi: 10.1016/j.omto.2017.05.004

How an alloreactive T-cell receptor achieves peptide and MHC specificity (2017). Wang Y, Singh NK, Spear TT, et al. Proc Natl Acad Sci U S A; 114 (24): E4792-e4801 doi: 10.1073/pnas.1700459114

Comparative exploration of multidimensional flow cytometry software: a model approach evaluating T cell polyfunctional behavior (2017). Spear TT, Nishimura MI, Simms PE. J Leukoc Biol; 102 (2): 551-561 doi: 10.1189/jlb.6A0417-140R

Biomarker profiling of plasma samples utilizing RANDOX biochip array technology (2017). Saluk J, Hoppensteadt D, Syed D, Liles J, Abro S, Walborn A et al. Int Angiol; 36 (6): 499-504 doi: 10.23736/s0392-9590.17.03854-8

Modulation of Interleukins in Sepsis-Associated Clotting Disorders: Interplay With Hemostatic Derangement (2017). Low C, Syed D, Khan D, Tetik S, Walborn A, et al. Clin Appl Thromb Hemost; 23 (1): 34-39 doi: 10.1177/1076029616659696

Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor (2017). Zak TJ, Koshman YE, Samarel AM, Robia SL. Biochemistry; 56 (35): 4722-4731 doi: 10.1021/acs.biochem.7b00616

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling (2017). Kumar A, Zamora-Pineda J, Degagné E, Saba JD. Mediators Inflamm; 2017: 7685142 doi: 10.1155/2017/7685142

2016

Ethanol intoxication prolongs post-burn pulmonary inflammation: role of alveolar macrophages (2016). Shults JA, Curtis BJ, Boe DM, Ramirez L, Kovacs EJ. J Leukoc Biol; 100 (5): 1037-1045 doi: 10.1189/jlb.3MA0316-111R

Advanced Age Alters Monocyte and Macrophage Responses (2016). Albright JM, Dunn RC, Shults JA, Boe DM, Afshar M, Kovacs EJ. Antioxid Redox Signal; 25 (15): 805-815 doi: 10.1089/ars.2016.6691

Alcohol and lung injury and immunity (2016). Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL, Brown LA. Alcohol; 55: 51-59 doi: 10.1016/j.alcohol.2016.08.005

Kupffer Cell p38 Mitogen-Activated Protein Kinase Signaling Drives Postburn Hepatic Damage and Pulmonary Inflammation When Alcohol Intoxication Precedes Burn Injury (2016). Chen MM, O'Halloran EB, Shults JA, Kovacs EJ. Crit Care Med; 44 (10): e973-9 doi: 10.1097/ccm.0000000000001817

Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders (2016). O'Halloran EB, Curtis BJ, Afshar M, Chen MM, Kovacs EJ, Burnham EL. Alcohol; 50: 43-50 doi: 10.1016/j.alcohol.2015.11.003

Neutrophil Accumulation in the Small Intestine Contributes to Local Tissue Destruction Following Combined Radiation and Burn Injury (2016). Carter SR, Chen MM, Palmer JL, Wang L, Ramirez L, Plackett TP, Gamelli RL, Kovacs EJ. J Burn Care Res; 37 (2): 97-105 doi: 10.1097/bcr.0000000000000220

Loss of Bin1 Promotes the Propagation of Tau Pathology (2016). Calafate S, Flavin W, Verstreken P, Moechars D. Cell Rep; 17 (4): 931-940 doi: 10.1016/j.celrep.2016.09.063

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization (2016). Samuel F, Flavin WP, Iqbal S, et al. J Biol Chem; 291 (9): 4374-85 doi: 10.1074/jbc.M115.705095

TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction (2016). Imam S, Talley S, Nelson RS, et al. J Virol; 90 (7): 3400-10 doi: 10.1128/jvi.03033-15

A multiplexed analysis approach identifies new association of inflammatory proteins in patients with overactive bladder (2016). Ma E, Vetter J, Bliss L, Lai HH, Mysorekar IU, Jain S. Am J Physiol Renal Physiol; 311 (1): F28-34 doi: 10.1152/ajprenal.00580.2015

Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors (2016). von Eichel-Streiber A, Paik W, Knight K, et al. Anaerobe; 41: 91-103 doi: 10.1016/j.anaerobe.2016.07.001

Factors Influencing the Management of Unruptured Intracranial Aneurysms (2016). Gillani RL, Podraza KM, Luthra N, Origitano TC, Schneck MJ. Cureus; 8 (5): e601 doi: 10.7759/cureus.601

Anti-Nogo-A Immunotherapy Does Not Alter Hippocampal Neurogenesis after Stroke in Adult Rats (2016). Shepherd DJ, Tsai SY, O'Brien TE, Farrer RG, Kartje GL. Front Neurosci; 10: 467 doi: 10.3389/fnins.2016.00467

Strategies to genetically engineer T cells for cancer immunotherapy (2016). Spear TT, Nagato K, Nishimura MI. Cancer Immunol Immunother; 65 (6): 631-49 doi: 10.1007/s00262-016-1842-5

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability (2016). Spear TT, Riley TP, Lyons GE, et al. J Leukoc Biol; 100 (3): 545-57 doi: 10.1189/jlb.2A1215-561R

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes (2016). Hellman LM, Yin L, Wang Y, … Spear TT, et al. J Immunol Methods; 432: 95-101 doi: 10.1016/j.jim.2016.02.016

How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire (2016). Blevins SJ, Pierce BG, Singh NK, … Spear TT, et al. Proc Natl Acad Sci U S A; 113 (9): E1276-85 doi: 10.1073/pnas.1522069113

TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors (2016). Spear TT, Callender GG, Roszkowski JJ, et al. Cancer Immunol Immunother; 65 (3): 293-304 doi: 10.1007/s00262-016-1800-2

Cardiac Calcium ATPase Dimerization Measured by Cross-Linking and Fluorescence Energy Transfer (2016). Blackwell DJ, Zak TJ, Robia SL. Biophys J; 111 (6): 1192-1202 doi: 10.1016/j.bpj.2016.08.005

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress (2016). Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD. J Exp Med; 213 (12): 2773-2791 doi: 10.1084/jem.20160287

2015

Experimental Approaches to Tissue Injury and Repair in Advanced Age (2015). Brubaker AL, Carter SR, Kovacs EJ. Methods Mol Biol; 1343: 35-51 doi: 10.1007/978-1-4939-2963-4_4

Extracellular traps and macrophages: new roles for the versatile phagocyte (2015). Boe DM, Curtis BJ, Chen MM, Ippolito JA, Kovacs EJ. J Leukoc Biol; 97 (6): 1023-35 doi: 10.1189/jlb.4RI1014-521R

Alcohol and inflammatory responses: summary of the 2013 Alcohol and Immunology Research Interest Group (AIRIG) meeting (2015). Morris NL, Ippolito JA, Curtis BJ, Chen MM, et al. Alcohol; 49 (1): 1-6 doi: 10.1016/j.alcohol.2014.07.018

Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin (2015). Chen MM, O'Halloran EB, Ippolito JA, Choudhry MA, Kovacs EJ. Shock; 43 (1): 80-4 doi: 10.1097/shk.0000000000000265

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases (2015). Cannova J, Breslin SJP, Zhang J. Front Med; 9 (3): 288-303 doi: 10.1007/s11684-015-0412-0

Impaired respiratory function and heightened pulmonary inflammation in episodic binge ethanol intoxication and burn injury (2015). Shults JA, Curtis BJ, Chen MM, O'Halloran EB, Ramirez L, Kovacs EJ. Alcohol; 49 (7): 713-20 doi: 10.1016/j.alcohol.2015.06.006

FYNagling divergent adhesive functions for Fyn in keratinocytes (2015). Fenton SE, Denning MF. Exp Dermatol; 24 (2): 81-5 doi: 10.1111/exd.12485

Prospects for Therapeutic Targeting of MicroRNAs in Human Immunological Diseases (2015). Luck ME, Muljo SA, Collins CB. The Journal of Immunology; 194 (11): 5047-5052 doi: 10.4049/jimmunol.1403146

Intestine immune homeostasis after alcohol and burn injury (2015). Li X, Hammer AM, Rendon JL, Choudhry MA. Shock; 43 (6): 540-8 doi: 10.1097/shk.0000000000000353

CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo (2015). Eby JM, Kang HK, Tully ST, Bindeman WE, Peiffer DS, et al. J Invest Dermatol; 135 (6): 1574-1580 doi: 10.1038/jid.2015.26

2014

Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses (2014). Curtis BJ, Hlavin S, Brubaker AL, Kovacs EJ, Radek KA. Alcohol Clin Exp Res; 38 (5): 1347-55 doi: 10.1111/acer.12369

The systemic immune response to trauma: an overview of pathophysiology and treatment (2014). Lord JM, Midwinter MJ, Chen YF, et al. Lancet; 384 (9952): 1455-65 doi: 10.1016/s0140-6736(14)60687-5

Street smarts of science for students (2014). Chen MM, Zahs A, Chang SL, Kovacs EJ. Nat Immunol; 15 (11): 997-9 doi: 10.1038/ni.2989

An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice (2014). Chen MM, Zahs A, Brown MM, et al. Am J Physiol Gastrointest Liver Physiol; 307 (7): G711-8 doi: 10.1152/ajpgi.00185.2014

Age-related differences in the neutrophil response to pulmonary pseudomonas infection (2014). Chen MM, Palmer JL, Plackett TP, Deburghgraeve CR, Kovacs EJ. Exp Gerontol; 54: 42-6 doi: 10.1016/j.exger.2013.12.010

Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region (2014). Sastri J, Johnsen L, Smolin N, Imam S, et al. J Virol; 88 (16): 8911-23 doi: 10.1128/jvi.01134-14

T cell IFN-γ suppression following alcohol and burn injury is independent of miRNA155 (2014). Li X, Rendon JL, Choudhry MA. PLoS One; 9 (8): e105314 doi: 10.1371/journal.pone.0105314

The role of aryl hydrocarbon receptor in interleukin-23-dependent restoration of interleukin-22 following ethanol exposure and burn injury (2014). Rendon JL, Li X, Brubaker AL, Kovacs EJ, Gamelli RL, Choudhry MA. Ann Surg; 259 (3): 582-90 doi: 10.1097/SLA.0b013e3182a626f2

2013

The aging lung (2013). Lowery EM, Brubaker AL, Kuhlmann E, Kovacs EJ. Clin Interv Aging; 8: 1489-96 doi: 10.2147/cia.S51152

G-CSF enhances resolution of Staphylococcus aureus wound infection in an age-dependent manner (2013). Brubaker AL, Kovacs EJ. Shock; 40 (4): 327-33 doi: 10.1097/SHK.0b013e3182a43651

Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age (2013). Brubaker AL, Rendon JL, Ramirez L, Choudhry MA, Kovacs EJ. J Immunol; 190 (4): 1746-57 doi: 10.4049/jimmunol.1201213

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia (2013). Risner LE, Kuntimaddi A, Lokken AA, Achille NJ, Birch NW, et al. J Biol Chem; 288 (41): 29901-10 doi: 10.1074/jbc.M113.474858

Intoxication by intraperitoneal injection or oral gavage equally potentiates postburn organ damage and inflammation (2013). Chen MM, Palmer JL, Ippolito JA, Curtis BJ, Choudhry MA, Kovacs EJ. Mediators Inflamm; 2013: 971481 doi: 10.1155/2013/971481

Combined radiation and burn injury results in exaggerated early pulmonary inflammation (2013). Palmer JL, Deburghgraeve CR, Bird MD, Hauer-Jensen M, Chen MM, et al. Radiat Res; 180 (3): 276-83 doi: 10.1667/rr3104.1

Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6 (2013). Chen MM, Bird MD, Zahs A, et al. Alcohol; 47 (3): 223-9 doi: 10.1016/j.alcohol.2013.01.004

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis (2013). Freeman D, Cedillos R, Choyke S, et al. PLoS One; 8 (4): e62143 doi: 10.1371/journal.pone.0062143

Increased expression of secreted frizzled-related protein-1 and microtubule-associated protein light chain 3 in keratoconus (2013). Iqbal O, Fisher G, Vira S, … Freeman D, et al. Cornea; 32 (5): 702-7 doi: 10.1097/ICO.0b013e318282987a

Noninvasive measurement of intestinal inflammation after burn injury (2013). Sigman M, Conrad P, Rendon JL, et al. J Burn Care Res; 34 (6): 633-8 doi: 10.1097/BCR.0b013e318280e2f8

Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury (2013). Rendon JL, Li X, Akhtar S, Choudhry MA. Shock; 39 (1): 11-8 doi: 10.1097/SHK.0b013e3182749f96